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Life and nature are filled with objects and molecules that are chiral. This means that they are mirror images of each other. Take the example of my hands. My hands are chiral, because they are not superimposable onto each other. This also means that my left hand does not fit a right handed glove. Many designer drugs, like XTC, are like my hands. They are chiral and the drug contains molecules that are mirror images of each other. This is very important, because this can significantly influence the effect of the drug in the body or their toxicity. Think of my body being filled with left and right handed receptors and enzymes that fit to a left or right handed drug. The effect of the chirality of designer drugs on the body is still largely unknown. Does it for instance influence the toxicity or the metabolism of the drug? What if a left handed drug is more potent or more toxic than a right handed drug? This is very important to know in many fields, especially forensic toxicology, to better understand and correctly interpret the drug concentrations that are measured in a body, dead or alive.

MIRROR IMAGES OF DESIGNER DRUGS: DOES IT MATTER?
ISABELLE KOHLERPROFILE
VU Amsterdam

Molecules can be mirror images of each other and therefore have different properties. These differences can be of great importance for drugs on the effect on our body. That's why Isabelle Kohler is researching left and right handed drugs.

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