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Every three seconds someone develops dementia. Dementia related diseases, like Parkinson's and Alzheimer's, remain some of the least understood and least treatable diseases. Why do people develop dementia? The syndrome is associated with the accumulation of proteins in the brain, which kill the neuronal cells and implicitly the communication between them. Unfortunately, current therapies only address symptoms and fail to focus on the underlying cause, let alone prevention. This is why, in my lab, we use computer simulations and AI to study dementia related proteins. We investigate how they behave at the super small nanoscopic scale and how their behaviour propagates at the macroscopic scale on the accumulations in the brain. These insights give us the opportunity to develop new therapies tailored for every stage of the disease. By combining elements of chemistry, physics, computational science and biology, we engineer solutions, solutions that open the door to new preventive therapies for diseases that targets someone every three seconds.

WHEN THE BRAIN FORGETS ITSELF
IOANA M. ILIEPROFILE
Van 't Hoff Institute for Molecular Sciences / UvA

Ioana Ilie seeks to understand and develop novel therapies against dementia-related diseases such as Parkinson’s and Alzheimer’s by using computer simulations and AI to study the proteins involved.

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